Extractable Nuclear Antigen Antibodies

Extractable Nuclear Antigen (ENA) Antibodies test detects the presence of autoantibodies. These autoantibodies react with “extractable” proteins,including Ro, La, Sm, RNP, Scl-70 and Jo1, when there’s a problem with the immune system. Thus, the test is used to identify autoimmune disorders.


In general, the result is positive or negative.

  • Positive: if the result is positive, then it’s likely that the person has an autoimmune disorder.
  • Negative: a negative result means there’s no autoantibody detected. So, the person may be safe from autoimmune disorders. In addition, if the person has symptoms, then they may be a result of other conditions.


Keywords: Anti-Jo-1; Anti-Ribonucleoprotein; Anti-RNP; Anti-Sjögren Syndrome A; Anti-Sjögren Syndrome B; Anti-Sm (Sm); Anti-SmRNP; Anti-SSA; Anti-SSB; Anti-Topoisomerase; Anti-U(1)RNP; Antibodies to Saline-extracted Antigens; Antihistidyl Transfer RNA Synthase Antibodies; Extractable Nuclear Antigen Antibodies; Extractable Nuclear Antigen Antibodies (ENA) Panel; Scl-70; Scleroderma Antibodies; Smith Antibody; SSA (Ro); SSB (La)

* The Content is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition.