Acetylcholinesterase (AChE)-Reference Range

Acetylcholinesterase, also known as AChE or acetylhydrolase, is the primary cholinesterase in the body. It is an enzyme that catalyzes the breakdown of acetylcholine and of some other choline esters that function as neurotransmitters. PChE is a kind of enzyme in the body.

The test of AChE and PChE in blood is helpful to determine if you have been exposed to and/or poisoned by certain organophosphate chemicals found in pesticides and to monitor cholinesterase levels if you work with pesticides.

Acetylcholinesterase ranges are stated in relation to hemoglobin and are 26.7 to 49.2 U/g of hemoglobin.

Pseudocholinesterase ranges are gender dependent:


  • All ages: 3100 to 6500 U/L


  • 18 to 49 years: 1800 to 6600 U/L
  • ≥ 50 years: 2550 to 6800 U/L

Decreased levels of AChE and PChE in blood.

Following exposure to organophosphate compounds, AChE and PChE activity can fall to about 80% of normal before any symptoms occur and drop to 40% of normal before the symptoms become severe.

Keywords: AChE; PChE


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