Adenosine deaminase (ADA) – Normal, High, Low

The reference range of adenosine deaminase (ADA) is 0-25 U/L.

Adenosine deaminase is a kind of enzyme which is important in the development and maintenance of the immune system.

A high value of ADA may indicate hepatitis and the M. tuberculosis infection in pleurae. And study found high level of a special kind of ADA called ADA2 may lead to autism. Besides, elevated levels of ADA have also been associated with AIDS.

A low value of ADA may not indicate tuberculosis, but it may cause severe combined immunodeficiency (SCID), particularly of autosomal recessive inheritance. Besides, low levels of ADA may be associated with pulmonary inflammation, thymic cell death, and defective T-cell receptor signaling.