Alzheimer biomarkers test, also known as Tau/Aß42 test, is a test conducted to distinguish Alzheimer disease from other forms of dementia. It not belongs to routine laboratory tests and only available in research setting or memory clinics.
Alzheimer biomarkers test measures amyloid beta 42 (Aß42) and tau protein in cerebrospinal fluid (CSF). Aß42 is peptide, increased production of it is responsible for the formation of senile plaques; Tau is a structural protein in the brain, which is responsible for producing neurofibrillary tangles.
Neurofibrillary tangles and senile plaques are regarded as the two main diagnostic features of Alzheimer disease.
Low levels of Aß42 CSF along with high levels of tau indicate Alzheimer disease.
Keywords: Alzheimer Biomarkers; Tau Protein and Amyloid Beta 42 Peptide; Tau/Aß42