Anti-Cyclic Citrullinated Peptide: Reference Range

Anti-cyclic citrullinated peptide refers to an antibody present in most rheumatoid arthritis patients. In a blood test, the doctor can test the levels of anti-CCP for a patient so as to diagnose if the patient is with rheumatoid arthritis.

In this test, blood will be collected first and the levels of anti-CCP will be examined. If the test result is positive, the patient is likely to have rheumatoid arthritis.

Often, a patient with rheumatoid arthritis and positive anti-CCP test result is called having seropositive rheumatoid arthritis. A patient with rheumatoid arthritis and negative anti-CCP arthritis is called having seronegative rheumatoid arthritis.

Reference range

Normal values (negative result) are <20 EU/mL. Positive results are classified as follows:

RangeResult
20-39 EU/mLWeakly positive
40-59 EU/mLModerately positive
>60 EU/mLStrongly positive

In general, 90% to 95% of people with a positive anti-CCP test have rheumatoid arthritis.

But in some cases, some patients with connective tissue disorders may also have positive anti-CCP test results. So, in order to confirm a diagnosis, further studies are often required.

Keywords: anti-cyclic citrullinated peptide; anti-CCP test.

* The Content is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition.