Anti-double-stranded DNA and Test Result

Anti-double stranded DNA antibody (anti-dsDNA) is one of a group of autoantibodies. Normally, antibodies protect against infection, but autoantibodies are produced when a person’s immune system fails to adequately distinguish between “self” and “non-self.” They mistakenly attack the body’s own healthy cells, causing tissue and organ damage.

What does the test result mean?

The test of anti-dsDNA is to help diagnose and monitor lupus. The possible results are as follows:

  • A high level of anti-dsDNA: the person tested very likely has lupus. This is especially true if an anti-Sm test is also positive.
  • Low to moderate levels: it may accompany with other autoimmune disorders, such as Sjögren syndrome and mixed connective tissue disease (MCTD).
  • A very low level: the result may be negative but does not exclude a diagnosis of lupus. Only about 65-85% of those with lupus will have anti-dsDNA.


Keywords: Anti-double-stranded DNA; anti-dsDNA

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