Antidiuretic hormone (ADH) Test

Antidiuretic hormone (ADH), also called arginine vasopressin (AVP), is a kind of hormone. By controlling the amount of the water kidneys reabsorb when filtering wastes out of the blood, the hormone helps regulate water balance in the body.


Three Main Types of Tests:

  • ADH suppression or stimulation test. With this test, a health practitioner is looking for appropriate levels of ADH, osmolality, and kidney water retention responses.
  • Water loading ADH suppression test. It can be used to help diagnose SIADH. With this test, those with SIADH typically have decreased blood sodium and osmolality.
  • Water deprivation ADH stimulation test. It may be used to differentiate between the two types of diabetes insipidus.


Interpretations of the Results:

  • Increased ADH levels are often associated with SIADH, which may be due to a variety of cancers, including leukemia, lymphoma, cancers of the lung, pancreas, bladder, and brain.Levels of ADH may be greatly increased with such cancers.
  • Moderate increases in ADH may be seen with nervous system disorders such as Guillain-Barré syndrome, multiple sclerosis, epilepsy, and acute intermittent porphyria.
  • A low ADH may associated with central diabetes insipidus, excessive water drinking, and with low serum osmolality.
  • An increased ADH may be seen with nephrogenic diabetes insipidus, with dehydration, trauma, and surgery.


Things Must Keep in Mind:

ADH test results alone are not diagnostic of a specific condition. The results are usually evaluated in conjunction with a person’s medical history, physical examination, and results of other tests.

Excesses and deficiencies of ADH may be temporary or persistent, acute or chronic, and may be due to an underlying disease, an infection, an inherited condition, or due to brain surgery or trauma.

Keywords: antidiuretic hormone; arginine vasopressin; AVP; SIADH; diabetes insipidus

* The Content is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition.