Antihistone Antibody

Histone antibodies are autoantibodies. These are antibodies produced by a person’s own immune system that target his or her own histones. This test detects the presence of histone antibodies in the blood.

Results of histone antibody testing consider several factors.

A positive result means that a person likely has drug-induced lupus if the person also has:

  • Symptoms associated with lupus
  • Been taking a drug, especially one associated with the condition, for several weeks to a couple of years
  • No identified autoimmune disorder prior to taking the drug
  • Positive ANA test
  • Low or negative anti-dsDNA and other autoantibodies
  • Signs and symptoms that resolve when the drug is discontinued
  • Histone antibody levels that begin to decrease when the drug is discontinued

A positive histone antibody result by itself does not establish a diagnosis. It needs further medical test.

A negative result means that the individual’s signs and symptoms may be due to a condition other than drug-induced lupus, such as a drug allergy.
However, a negative result does not rule out drug-induced lupus. A small portion of individuals may have drug-induced lupus even if they do not have histone antibodies.

* The Content is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition.