Apolipoprotein E (ApoE) is a class of proteins involved in the metabolism of fats in the body. ApoE genotype test is important in diagnosing Alzheimer’s disease and cardiovascular disease.
The ApoE protein has three genetic forms that have slightly different compositions. They are called ApoE2, ApoE3, and ApoE 4. ApoE3 is the most common form.
The normal range of ApoE in blood is 0.03～0.05g/L.
It should be noticed that:
- Elevated ApoE3 may not have any genetic impact on risk of developing cardiovascular disease.
- Elevated ApoE4 may be associated with an increased risk of atherosclerosis.
- Elevated ApoE2 may be associated with type III hyperlipoproteinemia/hyperlipidemia and premature vascular disease.
Keywords: ApoE; ApoE genotype tests