Atropine and Diphenoxylate: Uses & Side Effects

Atropine affects the body in many different ways, such as reducing spasms in the bladder, stomach, and intestines. Diphenoxylate is an antidiarrheal medication. Atropine and diphenoxylate is a combination medicine used to treat diarrhea in adults and children who are at least 13 years old.


What should you know before taking this medicine?

You should not use this medicine if you are allergic to atropine or diphenoxylate, or if you have:

  • Obstructive jaundice (a bile duct disorder that may cause yellowing of your skin or eyes);
  • Diarrhea that is caused by bacteria; or
  • Diarrhea caused by using antibiotic medication.

Tell your doctor if you have ever had:

  • A blockage in your intestines;
  • Ulcerative colitis;
  • Asthma or other breathing problems;
  • Glaucoma;
  • Urination problems;
  • Liver or kidney disease;
  • Down’s syndrome; or
  • If you are dehydrated.

It is not known whether this medicine will harm an unborn baby. Tell your doctor if you are pregnant. It may not be safe to breast-feed a baby while you are using this medicine. Ask your doctor about any risks.


Side effects

Some side effects may occur up to 30 hours after you take this medicine. Common side effects include:

  • Drowsiness, dizziness, feeling restless;
  • Headache;
  • Numbness in your hands or feet;
  • Depression, not feeling well;
  • Confusion, feelings of extreme happiness;
  • Red or swollen gums;
  • Dry mouth, nose, or throat;
  • Nausea, vomiting, upset stomach, loss of appetite; or
  • Skin rash, dryness, or itching.

Stop using this medicine and call your doctor at once if you have:

  • Severe constipation, stomach pain or bloating;
  • Ongoing or worsening diarrhea;
  • Diarrhea that is watery or bloody;
  • Severe pain in your upper stomach spreading to your back;
  • Fever, flushing (warmth, redness, or tingly feeling);
  • Hallucinations, seizure;
  • Rapid breathing, weak or shallow breathing;
  • Fast heart rate; or
  • Dehydration symptoms–feeling very thirsty or hot, being unable to urinate, heavy sweating, or hot and dry skin.


Keywords: atropine; diphenoxylate