Benzodiazepines:Uses, Side Effects

Benzodiazepines (also called “benzos”) are a class of agents that work in the central nervous system and are used for a variety of medical conditions. They act on specific receptors in the brain, called gamma-aminobutyric acid-A (GABA-A) receptors. Benzodiazepines attach to these receptors and make the nerves in the brain less sensitive to stimulation, which has a calming effect.

Benzodiazepines are primarily used for treating anxiety, but they also are effective in treating several other conditions. The exact mechanism of action of benzodiazepines is not known, but they appear to work by affecting neurotransmitters in the brain, chemicals that nerves release in order to communicate with other nearby nerves. Scientists believe that excessive activity of nerves may be the cause of anxiety and other psychological disorders, and benzodiazepines reduce the activity of nerves in the brain and spinal cord by enhancing the effects of GABA.

What are benzodiazepines used for?

Benzodiazepines may be used to treat:

  • alcohol withdrawal
  • anxiety
  • panic disorder
  • muscle relaxant
  • seizures

Side Effects

The most common side effects associated with benzodiazepines are:

  • sedation
  • dizziness
  • weakness
  • unsteadiness

Other side effects include:

  • transient drowsiness commonly experienced during the first few days of treatment
  • a feeling of depression
  • loss of orientation
  • headache
  • sleep disturbance
  • confusion
  • irritability
  • aggression
  • excitement
  • memory impairment

All benzodiazepines can cause physical dependence. Suddenly stopping therapy after a few months of daily therapy may be associated with withdrawal symptoms which include a feeling of loss of self-worth, agitation, and insomnia. If benzodiazepines are taken continuously for longer than a few months, stopping therapy suddenly may produce seizures, tremors, muscle cramping, vomiting, and sweating. In order to avoid withdrawal symptoms, the dose of benzodiazepines should be tapered slowly.

Keywords: Benzodiazepines

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