Beta-2 Microglobulin– Normal, High, Low

The reference range of B2M is 0~0.2mg/L.

A high value of B2M may indicate:

  • Multiple myeloma
  • Lymphoma
  • Primary amyloidosis
  • Secondary amyloidosis
  • Hepatitis
  • Nephritis
  • Rheumatoid arthritis
  • Immune diseases

A low value of B2M may indicate

  • Non-progression of HIV

In patients on long-term hemodialysis, B2M can aggregate into amyloid fibers that deposit in joint spaces, a disease, known as dialysis-related amyloidosis. B2M has other important function which is association with the HFE protein. Together with HFE protein B2M helps to regulate the expression of hepcidin in the liver. Loss of this function may cause iron excess and hemochromatosis.

* The Content is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition.