Bitter melon is
POSSIBLY SAFE for most people when taken by mouth short-term (up to 3 months). Bitter melon may cause an upset stomach in some people. The safety of long-term use of bitter melon is not known. There also is not enough information about the safety of applying bitter melon directly to the skin.
Special precautions & warnings:
Pregnancy and breast-feeding: Bitter melon is POSSIBLY UNSAFE when taken by mouth during pregnancy. Certain chemicals in bitter melon might start menstrual bleeding and have caused abortion in animals. Not enough is known about the safety of using bitter melon during breast-feeding. Stay on the safe side and avoid use.
Diabetes: Bitter melon can lower blood sugar levels. If you have diabetes and take medications to lower your blood sugar, adding bitter melon might make your blood sugar drop too low. Monitor your blood sugar carefully.
Glucose-6-phosphate dehydrogenase (G6PD) deficiency: People with G6PD deficiency might develop “favism” after eating bitter melon seeds. Favism is a condition named after the fava bean, which is thought to cause “tired blood” (anemia), headache, fever, stomach pain, and coma in certain people. A chemical found in bitter melon seeds is related to chemicals in fava beans. If you have G6PD deficiency, avoid bitter melon.
Surgery: There is a concern that bitter melon might interfere with blood sugar control during and after surgery. Stop using bitter melon at least 2 weeks before a scheduled surgery.
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