BRCA Gene Test - Breast or Ovarian Cancer

The BRCA gene test is a blood test that uses DNA analysis to identify harmful changes (mutations) in either one of the two breast cancer susceptibility genes — BRCA1 and BRCA2.

The test is to assess the risk of develop breast or ovarian cancer associated with hereditary mutations in the BRCA1 or BRCA2 genes.

Who to test

  • if you or someone in your family has had breast cancer before the age of 50
  • if you or someone in your family has had ovarian cancer at any age
  • if you or someone in your family is a male with breast cancer
  • if a BRCA1 or BRCA2 mutation has been identified in a family member

Test Preparation

BRCA gene test can be a blood sample from arm vein, or an oral rinse from the mouth

  • No preparation is needed for blood sample
  • For oral sample, it is recommended that you not eat, drink, or chew gum for at least an hour prior to your testing appointment, and no kissing immediately prior to testing.

Result

  • The presence of a BRCA1 or BRCA2 mutation means that the person tested is at an increased risk for developing hereditary breast and/or ovarian cancer syndrome.
  • According to the National Cancer Institute, estimates of lifetime risk for breast cancer in women are 55% to 65% for BRCA1 mutation and 45% for BRCA2 mutation. Risk of ovarian cancer is 39% with BRCA1 mutation and 11% to 19% with BRCA2 mutation.
Lifetime Risk BRCA1 Mutation BRCA2 mutation
Breast cancer 55%-65% 45%
Ovarian cancer 39% 11%-19%

 

 

 

* The Content is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition.