Caduet - amlodipine and atorvastatin

Caduet contains a combination of amlodipine and atorvastatin.

Atorvastatin is one of a group of statins. Atorvastatin reduces low density cholesterol and triglycerides in the blood.

Amlodipine is a calcium channel blocker. Amlodipine relaxes the blood vessels, improving blood flow and making it easier for the heart to pump.

Caduet is used to treat high blood pressure (hypertension) or chest pain (angina), and to lower the risk of stroke, heart attack, and other heart complications in people with type 2 diabetes, coronary heart disease, or other risk factors.

Caduet is used in adults and children who are at least 10 years old. Caduet is NOT for women in pregnancy or breastfeeding.

Usual Adult Dose of Caduet for Hyperlipidemia:

Initial dose: Amlodipine 5 mg-Atorvastatin 10 to 20 mg orally once a day

Maximum dose: Amlodipine 10 mg-Atorvastatin 80 mg orally once a day

Comments:

  • Small adult, fragile, or elderly patients may be started on amlodipine 2.5 mg orally once a day.
  • Most coronary artery disease patients will require amlodipine 10 mg orally once a day for adequate effect.
  • Patients who require greater than 45% low-density lipoprotein (LDL) reduction may be started on atorvastatin 40 mg orally once a day.
  • May be titrated for amlodipine after 1 to 2 weeks and for atorvastatin after 2 to 4 weeks.
  • Atorvastatin has not been studied in conditions where the major lipoprotein abnormality is elevation of chylomicrons (Fredrickson types I and V).

Usual Adult Dose of Caduet for Hypertension:

Initial dose: Amlodipine 5 mg-Atorvastatin 10 to 20 mg orally once a day

Maximum dose: Amlodipine 10 mg-Atorvastatin 80 mg orally once a day

Comments:

  • Small adult, fragile, or elderly patients may be started on amlodipine 2.5 mg orally once a day.
  • Most coronary artery disease patients will require amlodipine 10 mg orally once a day for adequate effect.
  • Patients who require greater than 45% low-density lipoprotein (LDL) reduction may be started on atorvastatin 40 mg orally once a day.
  • May be titrated for amlodipine after 1 to 2 weeks and for atorvastatin after 2 to 4 weeks.
  • Atorvastatin has not been studied in conditions where the major lipoprotein abnormality is elevation of chylomicrons (Fredrickson types I and V).

Usual Adult Dose of Caduet for Angina Pectoris:

Initial dose: Amlodipine 5 mg-Atorvastatin 10 to 20 mg orally once a day

Maximum dose: Amlodipine 10 mg-Atorvastatin 80 mg orally once a day

Comments:

  • Small adult, fragile, or elderly patients may be started on amlodipine 2.5 mg orally once a day.
  • Most coronary artery disease patients will require amlodipine 10 mg orally once a day for adequate effect.
  • Patients who require greater than 45% low-density lipoprotein (LDL) reduction may be started on atorvastatin 40 mg orally once a day.
  • May be titrated for amlodipine after 1 to 2 weeks and for atorvastatin after 2 to 4 weeks.
  • Atorvastatin has not been studied in conditions where the major lipoprotein abnormality is elevation of chylomicrons (Fredrickson types I and V).

Usual Adult Dose for Coronary Artery Disease:

Initial dose: Amlodipine 5 mg-Atorvastatin 10 to 20 mg orally once a day

Maximum dose: Amlodipine 10 mg-Atorvastatin 80 mg orally once a day

Comments:

  • Small adult, fragile, or elderly patients may be started on amlodipine 2.5 mg orally once a day.
  • Most coronary artery disease patients will require amlodipine 10 mg orally once a day for adequate effect.
  • Patients who require greater than 45% low-density lipoprotein (LDL) reduction may be started on atorvastatin 40 mg orally once a day.
  • May be titrated for amlodipine after 1 to 2 weeks and for atorvastatin after 2 to 4 weeks.
  • Atorvastatin has not been studied in conditions where the major lipoprotein abnormality is elevation of chylomicrons (Fredrickson types I and V).

Usual Adult Dose for Prevention of Cardiovascular Disease:

Initial dose: Amlodipine 5 mg-Atorvastatin 10 to 20 mg orally once a day

Maximum dose: Amlodipine 10 mg-Atorvastatin 80 mg orally once a day

Comments:

  • Small adult, fragile, or elderly patients may be started on amlodipine 2.5 mg orally once a day.
  • Most coronary artery disease patients will require amlodipine 10 mg orally once a day for adequate effect.
  • Patients who require greater than 45% low-density lipoprotein (LDL) reduction may be started on atorvastatin 40 mg orally once a day.
  • May be titrated for amlodipine after 1 to 2 weeks and for atorvastatin after 2 to 4 weeks.
  • Atorvastatin has not been studied in conditions where the major lipoprotein abnormality is elevation of chylomicrons (Fredrickson types I and V).

Side effects include:

More Common

  • Cough
  • difficulty with swallowing
  • dizziness
  • fast heartbeat
  • hives
  • itching
  • puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  • skin rash
  • tightness in the chest
  • unusual tiredness or weakness
  • wheezing

Rare

  • Chest pain or discomfort
  • dilated neck veins
  • extra heartbeats
  • extreme fatigue
  • irregular breathing
  • irregular heartbeat
  • pulse irregularity
  • swelling of the face, fingers, feet, or lower legs
  • weight gain
* The Content is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition.