What Are the Causes of Hemophilia B?

What are the causes of hemophilia B?

Generally speaking, there are two causes of hemophilia B. Most people develop the disease by inheriting from their mother, while some of the patients get it when genetic mutations occur before birth.

In our body, there is a protein called coagulation or clotting factors. With this protein, our body is able to form blood clots to stop bleeding. The process is called the coagulation cascade. However, if these clotting factors fail to function normally or are missing, excess bleeding is likely to occur.

The occurrence of hemophilia B is related to the deficit of factor IX. The defective gene is located on the X chromosome. Most patients inherit the disease from an inherited X-linked recessive trait.


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