Cisplatin: Uses & Sides Effects

Cisplatin is a cancer medication that interferes with the growth of cancer cells and slows their growth and spread in the body. Cisplatin is used together with other medications to treat bladder cancer, testicular cancer, or ovarian cancer.

How is cisplatin given?

Cisplatin is injected into a vein through an IV. You will receive this injection in a clinic or hospital setting.

You may be given IV fluids for 8 to 12 hours before you receive cisplatin.

Tell your caregivers if you feel any burning, pain, or swelling around the IV needle when cisplatin is injected.

Cisplatin can be harmful if it gets on your skin. If skin contact occurs, wash the area with soap and water.

Cisplatin can lower blood cells that help your body fight infections and help your blood to clot. Your blood will need to be tested often. Your cancer treatments may be delayed based on the results of these tests.


You should not receive this medication if you are allergic to cisplatin or similar medications such as carboplatin (Paraplatin) or oxaliplatin (Eloxatin). You should not receive cisplatin if you have kidney disease, bone marrow suppression, or hearing loss.

To make sure cisplatin is safe for you, tell your doctor if you have:

  • liver disease;
  • if you have ever received cisplatin in the past.

Using cisplatin may increase your risk of developing leukemia. Ask your doctor about your individual risk.

Do not use cisplatin if you are pregnant. It could harm the unborn baby. Use effective birth control, and tell your doctor if you become pregnant during treatment. Follow your doctor’s instructions about how long to prevent pregnancy after your treatment ends.

Cisplatin can pass into breast milk and may harm a nursing baby. Do not breast feed a baby while receiving this medication.

Serious side effects may be more likely in older adults using cisplatin.

Side Effects

Get emergency medical help if you have signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

  • hearing or vision problems, pain behind your eyes;
  • trouble with walking or daily activities;
  • numbness, tingling, or cold feeling in your hands or feet;
  • drowsiness, mood changes, increased thirst, little or no urinating;
  • swelling, weight gain, feeling short of breath;
  • pale skin, easy bruising, unusual bleeding (nose, mouth, vagina, or rectum), purple or red pinpoint spots under your skin;
  • fever, chills, body aches, flu symptoms, sores in your mouth and throat;
  • severe or ongoing vomiting;
  • chest pain or heavy feeling, pain spreading to the jaw or arm, nausea, sweating, general ill feeling;
  • sudden numbness or weakness (especially on one side of the body), sudden severe headache, problems with speech or balance;
  • low calcium (numbness or tingly feeling around your mouth, muscle tightness or contraction, overactive reflexes);
  • high or low potassium (confusion, tingly feeling, slow or uneven heart rate, weak pulse, extreme thirst, increased urination, leg discomfort, muscle weakness or limp feeling);
  • low sodium (slurred speech, hallucinations, vomiting, severe weakness, muscle cramps, loss of coordination, feeling unsteady, fainting, seizure, shallow breathing or breathing that stops).

Common side effects may include:

  • decreased sense of taste;
  • tired feeling;
  • temporary hair loss;
  • pain, swelling, burning, or irritation around the IV needle.


Cisplatin can harm your kidneys. This effect is increased when you also use certain other medicines, including: antivirals, chemotherapy, injected antibiotics, medicine for bowel disorders, medicine to prevent organ transplant rejection, and some pain or arthritis medicines (including aspirin, Tylenol, Advil, and Aleve).

Tell your doctor about all medicines you use, and those you start or stop using during your treatment with cisplatin, especially:

  • altretamine;
  • vitamin B6 (pyridoxine);
  • seizure medication.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Keyword: cisplatin.

* The Content is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition.