Clinical Trial - Fever After Simultaneous Versus Sequential Vaccination in Young Children - Fever
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Eligible children will be randomized to receive simultaneous or sequentially administered US licensed PCV13, US-licensed DTaP vaccine, and US-licensed inactivated influenza vaccine (IIV). Children in the simultaneous group will receive PCV13, DTaP, and IIV vaccines at Visit 1, and then return for a health education visit without vaccination about 2 weeks later (Visit 2). Children in the sequential group will receive both PCV13 and DTaP without IIV at Visit 1, and then will receive IIV and health education about 2 weeks later (Visit 2). Parents will record the occurrence of fever, solicited adverse events, medical care utilization, and receipt of antipyretics over 8 days following Visit 1 and Visit 2.
Study Type: |
Interventional  (Clinical Trial) |
Estimated Enrollment: |
280 participants |
Allocation: |
Randomized |
Intervention Model: |
Parallel Assignment |
Masking: |
None (Open Label) |
Primary Purpose: |
Prevention |
Official Title: |
A Prospective, Randomized, Open-label Clinical Trial to Assess Fever Following Simultaneous Versus Sequential Administration of PCV13, DTaP Vaccine and IIV in Young Children |
Actual Study Start Date: |
August 25, 2017 |
Estimated Primary Completion Date: |
March 2018 |
Estimated Study Completion Date: |
March 2018 |
Contact
Contact: Emmanuel B Walter, MD, MPH |
919-620-5346 |
chip.walter@duke.edu |
Contact: Christopher A Todd, MPH |
919-681-7791 |
chris.todd@duke.edu |
ClinicalTrials.gov Identifier: |
NCT03165981 |
For enrollment please visit www.clinicaltrials.gov.
* The Content is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition.
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