Clinical Trial – Side Effects of Combination Treatment for Melanoma – Melanoma

Melanoma is a cancer of melanocytes–melanin pigment producing cells, and the cancer originates in the skin, uvea, acral tissues and mucosal tissues. Melanoma incidence and mortality are increasing in the U.S. with over 80,000 cases/year and 9,000 deaths/year. Advanced melanoma occurs either after treatment for localized melanoma or de novo and is associated with chemo-resistance and a median survival of 9 months.

This study is being done to find out if the combination of dabrafenib, trametinib and digoxin will lessen the side effects that you may experience and to measure your response and duration of response to the combination of drugs.

Study Type  : Interventional  (Clinical Trial)
Estimated Enrollment  : 20 participants
Intervention Model: Single Group Assignment
Masking: None (Open Label)
Primary Purpose: Treatment
Official Title: A Phase 1B Clinical Trial of Dabrafenib, Trametinib Plus Digoxin in Patients With Unresectable or Metastatic BRAF V600 Mutant Melanoma
Study Start Date  : October 2016
Estimated Primary Completion Date  : July 2019
Estimated Study Completion Date  : July 2020
Contacts
Contact: Joyce Bolluyt, Rn 214-648-7097 Joyce.Bolluyt@UTSouthwestern.edu
Locations
United States, Texas
University of Texas Southwestern Medical Center Recruiting
Dallas, Texas, United States, 75063
Contact: Joyce Bolluyt, RN    214-648-7097    joyce.bolluyt@utsouthwestern.edu
Principal Investigator: Arthur Frankel, MD

 

ClinicalTrials.gov Identifier: NCT02915666

 

* The Content is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition.