Clinical Trials-Effects of Enriched Fruit Juice on Blood Glucose Levels After a Meal-Blood Tests

This study is designed to determine whether polyphenols, as normally and naturally present in food extracts and beverages, added to a carbohydrate-rich meal, can lower blood glucose levels after its consumption, and hence lower its glycaemic index, and if this effect is mediated through effects on insulin and other hormones. The study is designed as an acute, double-blind, randomised, placebo-controlled crossover trial in 24 healthy subjects with normal glycaemic response to white bread. Participants will be asked to consume either white bread with pomegranate juice enriched with extracts from grape seeds and apple peels or white bread with placebo drink. The effects on plasma glucose levels, levels of hormones and other biomarkers involved in postprandial response will be determined over 3 hours after the consumption.

Study Type  : Interventional  (Clinical Trial)
Estimated Enrollment  : 24 participants
Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary Purpose: Prevention
Official Title: Effects of Enriched Fruit Juice on Blood Glucose Levels After a Meal in Healthy Subjects
Actual Study Start Date  : April 10, 2017
Estimated Primary Completion Date  : February 9, 2018
Estimated Study Completion Date  : September 1, 2018
Contacts
Contact: Gary Williamson, PhD +441133438380 G.Williamson@leeds.ac.uk
Contact: Aleksandra Konic Ristic, PhD +441133432979 A.KonicRistic@leeds.ac.uk
Locations
United Kingdom
School of Food Science and Nutrition, University of Leeds Recruiting
Leeds, West Yorkshire, United Kingdom, LS2 9JT
Contact: Gary Williamson, PhD    +441133438380    G.Williamson@leeds.ac.uk
Contact: Aleksandra Konic Ristic, PhD    +441133432979    a.konicristic@leeds.ac.uk
ClinicalTrials.gov Identifier: NCT03255876