Cold Agglutinin Test

Cold agglutinins are antibodies that, instead of helping to fight bad things like bacteria in your body, attack your red blood cells. Cold agglutinin test is used to help determine the cause of hemolytic anemia and to help diagnose cold agglutinin disease.

The result of a cold agglutinin test is typically reported as a titer, the normal range of cold agglutinin is less than 1∶64.

Increased cold agglutinins may indicate

  • Cold agglutinin disease.
  • Mycoplasma pneumonia.
  • Liver cirrhosis.
  • Mycoplasma pneumoniae infections: about 75% of those who are infected will have increased cold agglutinins.
  • Mono (infectious mononucleosis): more than 60% of those affected will have increased cold agglutinins.
  • Cancers, including lymphoma, leukemia, and multiple myeloma.
  • Bacterial infections, such as Legionnaires disease and syphilis.
  • Viral infections such as HIV, influenza, CMV, EBV, hepatitis C.
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