Compound Benefits Cognition in Alzheimer's

National Institute on Aging (NIA) has recently released its finding in treating Alzheimer’s disease.

In the research, the supplement nicotinamide riboside (NR) – a form of vitamin B3 – shows the result of preventing neurological damage and improving cognitive and physical function in a new mouse model of Alzheimer’s disease.

NR acts on the brain by normalizing levels of nicotinamide adenine dinucleotide (NAD+), a metabolite vital to cellular energy, stem cell self-renewal, resistance to neuronal stress and DNA repair. In Alzheimer’s disease, the brain’s usual DNA repair activity is impaired, leading to mitochondrial dysfunction, lower neuron production, and increased neuronal dysfunction and inflammation.

In the lab study, the mice treated with NR showed less DNA damage, higher activity and reorganization of brain cells associated with learning or memory.

Next step of the research include further studies in human.

 

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