Cryoglobulins Test Result and Interpretation

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The cryoglobulins test detects and measures the relative quantity of cryoglobulins in the blood. Cryoglobulins are circulating proteins and may be present in small quantities in the blood of some healthy people. But they are most frequently associated with a variety of diseases and conditions.

What does the test result mean?

The test is negative in most healthy people.

If the test is positive, it means that cryoglobulins are present and have the potential to precipitate upon exposure to cold. A positive test for cryoglobulins may indicate numerous conditions. Some examples include:

  • Infections such as Lyme disease, infectious mononucleosis (mono), hepatitis C and HIV/AIDS
  • Kidney disease
  • Autoimmune diseases such as systemic lupus erythematosus, rheumatoid arthritis, and Sjögren syndrome
  • Diseases characterized by an increase in lymphocytes such as multiple myeloma, lymphoma and lymphoid leukemia
  • Disorders associated with inflammation of blood vessels (vasculitis)

However, the cryoglobulins test is not diagnostic of a specific underlying condition.


Keywords: cryoglobulins test; cryocrit; cryoprotein

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