Dabrafenib: Uses & Sides Effects

Dabrafenib is a cancer medication that interferes with the growth and spread of cancer cells in the body.

Dabrafenib is used alone or in combination with another medicine called trametinib (Mekinist) to treat certain types of cancer in people who have a “BRAF” gene mutation. dabrafenibs is for use in treating:

  • melanoma (skin cancer) that cannot be treated with surgery or has spread to other parts of the body, or to prevent melanoma from coming back after surgery;
  • non-small cell lung cancer that has spread to other parts of the body; or
  • advanced or metastatic thyroid cancer that has spread and for which there are no other treatment options.

How should I take dabrafenib?

Your doctor will perform blood tests to make sure you have the correct tumor type to be treated with dabrafenib.

Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed.

Take dabrafenib on an empty stomach, at least 1 hour before or 2 hours after a meal.

Swallow the capsule whole and do not crush, chew, break, or open it.

If you need surgery, dental work, or a medical procedure, tell the doctor you currently use dabrafenib.

Your doctor will need to check your skin every 2 months while you are using dabrafenib, and for up to 6 months after your treatment ends.

Store at room temperature away from moisture and heat.

Precautions

You should not use dabrafenib if you are allergic to it.

Tell your doctor if you have ever had:

  • heart disease;
  • bleeding problems;
  • liver or kidney disease;
  • diabetes (dabrafenib may raise your blood sugar);
  • eye problems (especially a problem with your retina);
  • a genetic enzyme deficiency called glucose-6-phosphate dehydrogenase (G6PD) deficiency.

Using dabrafenib with trametinib may increase your risk of developing a certain type of skin cancer. Ask your doctor about your specific risk. Tell your doctor if you notice any new skin symptoms such as redness, warts, sores that will not heal, or a mole that has changed in size or color.

Do not use dabrafenib if you are pregnant. It could harm the unborn baby. Tell your doctor if you become pregnant during treatment. Use effective birth control to prevent pregnancy while you are using dabrafenib.

  • If you use dabrafenib alone: Keep using birth control for at least 2 weeks after your last dose.
  • If you use dabrafenib and trametinib together: Keep using birth control for at least 4 months after your last dose of these two medicines.

Dabrafenib can make hormonal birth control less effective (birth control pills, injections, implants, skin patches, vaginal rings). Use a condom or diaphragm with spermicide to prevent pregnancy.

This medicine may affect fertility (ability to have children) in both men and women. However, it is important for women to use birth control to prevent pregnancy because dabrafenib can harm an unborn baby.

You should not breast-feed while using this medicine and for at least 2 weeks after your last dose (or 4 months after your last dose of dabrafenib with trametinib).

Side Effects

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Some side effects are more likely to occur if you take dabrafenib and trametinib together. Call your doctor at once if you have:

  • fever, chills, feeling light-headed or short of breath;
  • pale or yellowed skin, dark colored urine;
  • eye pain or swelling, vision changes, seeing halos around lights, seeing color “dots” in your vision;
  • severe skin rash, skin pain or swelling, redness and peeling skin on your hands or feet;
  • increased thirst or urination;
  • signs of bleeding–weakness, dizziness, headache, bloody or tarry stools, coughing up blood or vomit that looks like coffee grounds;
  • signs of a heart problem–shortness of breath (even with mild exertion), pounding heartbeats, swelling in your feet or ankles.

Common side effects may include:

  • headache, muscle or joint pain;
  • bleeding;
  • fever, chills, tiredness;
  • dry skin, thickened skin, warts, rash;
  • swelling in the legs, arms, and face;
  • nausea, vomiting, diarrhea, loss of appetite;
  • cough, trouble breathing;
  • temporary hair loss.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Keyword: dabrafenib.

* The Content is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition.