Dantrolene:Uses, Side effects

Dantrolene is a muscle relaxer.

Dantrolene is used to treat muscle spasticity (stiffness and spasms) caused by conditions such as a spinal cord injury, stroke, cerebral palsy, or multiple sclerosis.

Dantrolene is also used to prevent muscle stiffness and spasms caused by malignant hyperthermia (a rapid rise in body temperature and severe muscle contractions) that can occur during surgery with certain types of anesthesia.

Dantrolene may also be used for purposes not listed in this medication guide.

Important Information

You should not use dantrolene if you have active liver disease. Do not use dantrolene at a time when you need muscle tone for safe balance and movement during certain activities.

Dantrolene can cause life-threatening liver damage, especially if you take high doses. Do not take dantrolene in larger amounts or for longer than recommended.

Call your doctor right away if you have signs of liver problems such as nausea, upper stomach pain, loss of appetite, dark urine, clay-colored stools, or jaundice (yellowing of the skin or eyes).

Side effects

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor right away if you have signs of liver problems–nausea, upper stomach pain, itching, tired feeling, loss of appetite, dark urine, clay-colored stools, or jaundice (yellowing of the skin or eyes). These side effects may be most likely to occur between 3 and 12 months of your treatment with dantrolene.

Also call your doctor right away if you have:

  • muscle weakness
  • severe drowsiness
  • vomiting
  • severe diarrhea

Dantrolene can cause muscle weakness, which can affect your ability to swallow. Use caution to prevent choking while you are eating meals. Talk with your doctor if you are unable to eat because of this side effect.


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