Denosumab is a monoclonal antibody. Monoclonal antibodies are made to target and destroy only certain cells in the body. This may help to protect healthy cells from damage.
The Prolia brand of denosumab is used to treat osteoporosis in postmenopausal women who have high risk of bone fracture. Prolia is also used to increase bone mass in women and men with a high risk of bone fracture caused by receiving treatments for certain types of cancer.
This medication guide provides information about the Prolia brand of denosumab. Xgeva is another brand of denosumab used to prevent bone fractures and other skeletal conditions in people with tumors that have spread to the bone.
Denosumab may also be used for purposes not listed in this medication guide.
This medication guide provides information about the Prolia brand of denosumab. Xgeva is another brand of denosumab used to prevent bone fractures and other skeletal conditions in people with tumors that have spread to the bone.
You should not receive denosumab if you have low levels of calcium in your blood (hypocalcemia).
Prolia can harm an unborn baby or cause birth defects. Do not use if you are pregnant.
You should not receive Prolia if you are allergic to denosumab, or if you have low levels of calcium in your blood (hypocalcemia).
While you are using Prolia, you should not receive Xgeva, another brand of denosumab.
To make sure Prolia is safe for you, tell your doctor if you have:
Denosumab may cause bone loss (osteonecrosis) in the jaw. Symptoms include jaw pain or numbness, red or swollen gums, loose teeth, gum infection, or slow healing after dental work.
Osteonecrosis of the jaw may be more likely if you have cancer or received chemotherapy, radiation, or steroids. Other risk factors include blood clotting disorders, anemia (low red blood cells), and a pre-existing dental problem.
Denosumab can harm an unborn baby or cause birth defects. Do not use Prolia if you are pregnant. Tell your doctor right away if you become pregnant during treatment.
It is not known whether denosumab passes into breast milk or if it could harm a nursing baby. denosumab may also slow the production of breast milk. You should not breast-feed while using denosumab.
Get emergency medical help if you have signs of an allergic reaction: hives, itching, rash; difficult breathing, feeling light-headed; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have:
Serious infections may occur during treatment with Prolia. Call your doctor right away if you have signs of infection such as:
Common side effects may include:
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.
Other drugs may interact with denosumab, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell each of your health care providers about all medicines you use now and any medicine you start or stop using.
Keywords: denosumab; Prolia.