Does Aspirin Work for Patients with Venous Leg Ulcers In An Adjuvant Way?

Low-dose aspirin conferred no benefit over standard compression therapy alone.

Compression therapy is the mainstay of treatment for patients with venous leg ulcers. Such patients have higher platelet counts and greater platelet reactivity than people without venous leg ulcers. Aspirin interrupts platelet activity, but whether adjuvant aspirin treatment hastens leg ulcer healing is unclear.

According to research, median time to complete healing of the reference ulcers (the largest ulcer, if more than 1 was present) was 77 days in the aspirin group and 69 days in the placebo group — a non-significant difference. At the end of the study, complete healing did not differ significantly between groups (70% and 80% in the aspirin and placebo groups, respectively) nor did estimated change in ulcer area (4.1 cm2 and 4.8 cm2, respectively). Quality of life and adverse effects were similar in the two groups.

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