TACROLIMUS: FDA Approved Drugs and User Comments

User Comments:

For Organ Transplant, Rejection Prophylaxis: “I started taking tacrolimus 11 years ago, for the first 2 years no problems. but then I started having reactions to foods, breaking out in bright red rashes, super hypertensive episodes, like 190/100. shaking. itching. tongue burning which goes from bad to bloody awful some days. I start choking, unable to swallow and a severe rash that came on my face, had to call the ambulance. It has completely changed my metabolism where I can’t take any other meds without serious reactions .”

Nakirallyn January 20, 2018

Prograf (tacrolimus) for Organ Transplant, Rejection Prophylaxis: “All praises to program. I have not had any problems with rejections. Liver transplant Date 2011. I’ve had some itching and my sleeping is awful. But my main problem follows. I have developed NODM (New Onset Diabetes Management) and I simply cannot lose weight, instead , I am gaining and CANNOT LOSE. I EXERCISE AT LEAST 1 1/2 HRS DAILY, MY DIET IS EXCELLENT AND I’M A MODEL PATIENT. Yet my post transplant diabetes is out of control. I am hovering around 7.0 and I am literally killing myself exercising, eating right, taking meds correctly, etc. Been seen by 4 Endocrinologists….more oral meds and more insulin. Just this week, I’m been told to take Glipizide maximum daily dose, Novolog insulin, 9 units X3, Novolin 28Us/10Us & Junevia”

1DrMadison2 November 28, 2017

For Crohn’s Disease: “I was in the original FDA FK506 study as a pre-transplant patient (Primary Sclerosing Cholangitis ). I had been given 6 yrs to have a liver transplant. My liver #’s were 3-4 digits and I was becoming very ill. My dosage was stabilized at 3 mgs and my numbers have decreased to normal. I have been on this medicine since 10 ’92 and still no transplant. The medicine has slowed the progress of PSC drastically. I see it is used for Crohn’s, but nothing is listed for liver diseases. Did they ever evaluate the trial results from the early 90’s? My current insurance will not approve the drug for me for this reason. This might be the result of the trial www.ncbi.nlm.nih.gov/pmc/articles/PMC2982698/ or is a similar one.”

Weavr September 19, 2017

Prograf (tacrolimus) for Organ Transplant, Rejection Prophylaxis: “Itching was bad in lower legs especially my ankles for a few months after liver transplant in June 2016. I had hand trembling where it was hard to write or hold things steady like utensils for several months. These cleared up about 3 months out from transplant. Also, though lesser in degree was dizziness, confusion, tingling in legs, prickly feeling in legs, fatigue, loss of taste, urination about every hour at night. These decreased or ceased after 4 months. I have put back on weight (40 lbs) that I needed to put on and am now stable at a healthy weight.Overall, taking prograf now, one year out, is good. Though I am having trouble sleeping thru the night. I wake up around 3 am and do not get back to sleep until 5-6 am.”

Mayoclinic patient (taken for 1 to 2 years) June 14, 2017

For Crohn’s Disease: “I have an autoimmune condition AntiSynthtase Syndrome, ILD and Dermatomyositis .I have been on Tacrolimus for approximately 2 months. I was on it previously as an interim drug before I received Rituximab and before that I had nine rounds of CYclophosphamide. I have also tried Mycofenelate whilst I was have Rituximab.”

Anonymous (taken for 1 to 6 months) May 3, 2017

For Organ Transplant, Rejection Prophylaxis: “I read where prograf does not work well on people of color. I started with 12 pills a dayweakened my entire body. Now on 8 pills a day, every so often it weakens my body. Cant stand for long periods of time, I get tired and feel very weak. right now searching for an answer, dr. contacted today”

ginger sue (taken for 1 to 2 years) April 29, 2016

* The Content is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition.