TRENTAL: FDA Approved Drugs and User Comments

Drug Name	Active Ingredients	Strength	Dosage Form/Route	Marketing Status
TRENTAL	PENTOXIFYLLINE	400MG Federal Register determination that product was not discontinued or withdrawn for safety or efficacy reasons	TABLET, EXTENDED RELEASE;ORAL	Discontinued

User Comments:

For Intermittent Claudication “I have had significant leg pain for a long time. This medication took about 1-2 months to start working, but then it was great. I could run on the treadmill at much faster speeds and for much longer – when previously I’d have cramps. Also, standing stationary used to be painful after 5-10 minutes – but this also improved. The only problem is that this medication can cause anxiety and insomnia since it is derived from xanthine (chemical “cousin” of caffeine). This is listed as a rare side effect on the drug insert, but I have heard it is more common from my doctor. I was actually given this for Peyronie’s disease (off-label), but it didn’t do much for that. It is supposed to inhibit TGF-beta (a cytokine) – decreasing scar tissue.”

peter4911 (taken for 1 to 2 years) May 4, 2015

For Intermittent Claudication “I experienced what is described as “blue/purple finger(s)” in my left hand. After an intensive vascular examination, this was determined to be caused by vascular spasms. After being prescribed Trental by my doctor. The blue/purple condition of my hand fingers returned to normal skin color in about two or three days. There were no noticeable side effects and when I stopped taking the medication, the condition did not return to “blue/purple” and to date remains a normal skin color.”

Anonymous July 4, 2011

For Intermittent Claudication “I found TRENTAL very helpful with my leg pain. Without it I can hardly walk. With other medicines if I take enough pain killers that I can walk I can hardly stay awake. Afraid to drive for any distance more than 20 miles.”

handyman31 March 20, 2010

* The Content is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition.