FIP1L1-PDGFRA Fusion by FISH or RT-PCR Results

FIP1L1-PDGFRA Fusion by FISH or RT-PCR Test, also known as 4q12 (CHIC2) deletion test, is used to investigate the cause of hypereosinophilia (HE) or hypereosinophilic syndrome (HES) and help determine whether the person with HE/HES could be treated with certain inhibitors like imatinib.

Results and Meanings:

  • Positive: A positive result for a person who has abnormally high numbers of eosinophils (a variety of white blood cells) means the FIP1L1-PDGFRA fusion gene is the cause of HE/HES. And he/she will respond well to the treatment with the tyrosine kinase inhibitor imatinib.
  • Negative: A negative result means the person may have another type of disease, or that he/she may have HES without a specific cause. In such case, treatment with imatinib will not be suitable (with exceptions).


Keywords: 4q12 (CHIC2) deletion, FIP1-like-1/platelet-derived growth factor alpha, FIP1L1-PDGFRA, FIP1L1-PDGFRA Fusion by FISH or RT-PCR, HES/Leukemia, PDGFRA-FIP1L1 gene rearrangement

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