Hb S Test

Hb S test, also known as Hemoglobin S Evaluation, is used to determine if one has sickle cell trait or sickle cell disease.

A blood sample would be drawn from a vein in your arm or, for infants, by pricking a heel or finger. No specific test preparation is needed, but if this test is used for diagnosis, the sample should not be drawn after a recent blood transfusion.

The test is needed in several cases.

  • routinely as part of newborn screening
  • if you are in a high risk group and were born before newborn screening was mandated and want to know if you have sickle cell disease or are carrying the sickle cell trait
  • when you have signs and symptoms of anemia or abnormal results from a complete blood count (CBC) and your healthcare practitioner suspects sickle cell disease or trait

Normal results are negative, meaning no sickle cells were seen.

Positive results mean sickle cells were seen. Your healthcare provider will confirm these results with hemoglobin electrophoresis. A positive result may also mean that you have another blood disease and may need more tests.


Keywords: Hb S, Hemoglobin S, Hemoglobin S Evaluation, Hgb S, Sickle Cell Tests

* The Content is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition.