Hemihypertrophy: Symptom, Treatment


Hemihypertrophy, also called hemihyperplasia, is a rare disorder in which one side of the body grows more than the other due to an excess production of cells, thus causing asymmetry.

This disorder is congenital. Once being affected, the body will continue to grow or enlarge abnormally.


Common symptoms of hemihypertrophy include:

  • The tendency for one side of the body to be larger than the other side
  • An arm or a leg can be longer or larger in circumference
  • Wilms tumor, a cancer occurring in the kidneys
  • Hepatoblastomas of the liver
  • Adrenocortical carcinomas of the adrenal gland
  • Leiomyosarcomas of the muscle

Children with hemihypertrophy are at a higher risk for tumors, especially those that occur in the abdomen.


It is not clear what the exact causes for hemihypertrophy are, but evidences show that hemihypertrophy may be associated with the mutation on chromosome 11.


Physical examination and certain diagnostic imaging tests are the two common diagnostic methods for hemihypertrophy.

Because the symptoms of it are similar to other conditions like Beckwith-Wiedemann syndrome (BWS), Proteus syndrome, Russell-Silver syndrome and Sotos syndrome, these two tests can help rule out them.


There is no cure for hemihypertrophy. The concentration of the treatment is observing tumor growth and treating the tumors. For certain symptoms like abnormal size of limb, doctors will recommend orthopedic treatment and corrective shoes.

Keywords: hemihypertrophy; hemihyperplasia.

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* The Content is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition.