Higher Vitamin D Lower Cancer Risk

High levels of vitamin D reduce the risk of cancer, including liver cancer, according to a research published in BMJ from a national research team. In the research report, the international research team found evidence that high levels of vitamin D can effectively reduce the risk of multiple cancers including liver cancer.

In this study, the researchers stated that their findings support the theory that vitamin D may help prevent cancer. Vitamin D is obtained in the sun. It helps to maintain calcium levels in the body and keep bones, teeth and muscles healthy. Although the benefits of vitamin D in bone disease are well known, there is increasing evidence that vitamin D may be beneficial to other chronic diseases, including some cancers.

But so far, most studies have been conducted in European or American populations, and the evidence for Asian populations is limited. Since the concentration and metabolism of vitamin D may vary from race to race, it is important to find out whether similar effects can be seen in non-white populations. Therefore, an international research team headquartered in Japan started to assess whether vitamin D is related to the risk of specific cancers.

They analyzed a prospective (JPHC) study based on the Japanese Public Health Center, which involved 33,736 male and female participants aged 40 to 69 years. At the start of the study, participants provided detailed information about their medical history, diet, and lifestyle, and collected blood samples to measure vitamin D levels.

The level of vitamin D varies with the sampling time and is higher in summer and autumn than in winter or spring. After considering this seasonal change, the samples were divided into four groups, from the lowest to the highest levels of vitamin D. Participants were subsequently monitored for an average of 16 years, during which 3301 new cancer cases were recorded. After adjusting for known cancer risk factors such as age, body mass (BMI), physical activity levels, smoking, alcohol intake, and dietary factors, the researchers found that men and women with higher vitamin D levels have cancer The relative risk is low (about 20%).


Higher vitamin D levels are also associated with a lower relative risk of liver cancer (30% to 30%), and men are more pronounced than women. No association was found between lung cancer or prostate cancer, and the authors pointed out that none of the cancer tests showed an increased risk of high vitamin D levels. The results of the survey were essentially unchanged because of the additional dietary factors that needed further analysis to test the power of the results.

The researchers pointed out the limitations of some studies, such as the relatively small number of organ-specific cancers. Although they have adjusted several known risk factors, they cannot rule out the possibility that other unmeasurable factors may affect the results, so it is difficult to make a firm conclusion about cause and effect.

However, the main advantages include a large overall cancer sample, long follow-up times, and analysis of large blood samples. The authors say that their findings support the theory that vitamin D can prevent cancer risk, but it may also have a capping effect, which may suggest that there are no additional benefits beyond vitamin D.



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