HIV Genotypic Anti-retroviral Drug Resistance Testing

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If a person has been diagnosed with human immunodeficiency virus (HIV), the anti-retroviral drug resistance testing can help determine whether the strain:

  • is resistance to one or more antiretroviral therapy (ART) drugs, or
  • have developed resistance to one or more ART drugs.
What does the test result mean?

The test analyzes the genes of the HIV strain of the patient, so it can help identify mutations causing the virus to be resistant to ART. The results are descibed by a combination of letters and numbers (for example, K103N). The letters refer to the amino acid associated with the gene. The numbers indicate the position of the mutation in the genome.

The laboratory report may also give an explanation and a list of the drugs to which the virus is either resistant or susceptible. This helps a doctor select a treatment strategy that is most likely to suppress the patient’s HIV.

Keywords: anti-retroviral drug resistance testing; HIV

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