Immunoglobulins (IgA, IgM, IgG, IgD, IgE) - Normal Range

Immunoglobulins (IgA, IgM, IgG, IgD, IgE) are antibodies that play an important role in fighting infections. There are 5 different types of immunoglobulins in your blood, which scientists have named IgA, IgM, IgG, IgD, and IgE. Each of these has a slightly different role to play in your immune system.

In normal serum, about 80% is immunoglobulin G (IgG), 15% is immunoglobulin A (IgA), 5% is immunoglobulin M (IgM), 0.2% is immunoglobulin D (IgD), and a trace is immunoglobulin E (IgE).

Elevations of IgG, IgA, and IgM may be due to polyclonal immunoglobulin production, conditions including SLE, infection, liver disease, multiple myeloma, and others. 

In multiple myeloma, the malignant (or cancerous) myeloma cells may produce large amounts of one type of immunoglobulin. Blood test for the levels of immunoglobulins helps determine which specific type of myeloma one may have. IgG and IgA myelomas are the most common.

Monoclonal elevations of IgM occur in macroglobulinemia.

Decreased immunoglobulin levels are found in patients with immunodeficiency.

 

Reference range

IgG

0 – 5 months: 100-334 mg/dL

5 – 9 months: 164-588 mg/dL

9 – 15 months: 246-904 mg/dL

15 – 24 months: 313-1,170 mg/dL

2 – 4 years: 295-1,156 mg/dL

4 – 7 years: 386-1,470 mg/dL

7 – 10 years: 462-1,682 mg/dL

10 – 13 years: 503-1,719 mg/dL

13 – 16 years: 509-1,580 mg/dL

16 – 18 years: 487-1,327 mg/dL

>= 18 years: 767-1,590 mg/dL

IgA

0 – 5 months: 7-37 mg/dL

5 – 9 months: 16-50 mg/dL

9 – 15 months: 27-66 mg/dL

15 – 24 months: 36-79 mg/dL

2 – 4 years: 27-246 mg/dL

4 – 7 years: 29-256 mg/dL

7 – 10 years: 34-274 mg/dL

10 – 13 years: 42-295 mg/dL

13 – 16 years: 52-319 mg/dL

16 – 18 years: 60-337 mg/dL

>= 18 years: 61-356 mg/dL

IgM

0 – 5 months: 26-122 mg/dL

5 – 9 months: 32-132 mg/dL

9 – 15 months: 40-143 mg/dL

15 – 24 months: 46-152 mg/dL

2 – 4 years: 37-184 mg/dL

4 – 7 years: 37-224 mg/dL

7 – 10 years: 38-251 mg/dL

10 – 13 years: 41-255 mg/dL

13 – 16 years: 45-244 mg/dL

16 – 18 years: 49-201 mg/dL

>= 18 years: 37-286 mg/dL

IgD

<=10 mg/dL

IgE

0 – 5 months: <= 13 kU/L

6 – 11 months: <= 34 kU/L

1 – 2 years: <= 97 kU/L

3 years: <= 199 kU/L

4 – 6 years: <= 307 kU/L

7 – 8 years: <= 403 kU/L

9 – 12 years: <= 696 kU/L

13 – 15 years: <= 629 kU/L

16 – 17 years: <= 537 kU/L

>= 18 years: <= 214 kU/L

* The Content is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition.