L-arginine is
POSSIBLY SAFE for most people when taken appropriately by mouth, administered as a shot, or applied to the skin, short-term. It can cause some side effects such as abdominal pain, bloating, diarrhea, gout, blood abnormalities, allergies, airway inflammation, worsening of asthma, and low blood pressure.
Special precautions & warnings:
Pregnancy and breast-feeding: L-arginine is POSSIBLY SAFE when taken by mouth appropriately for a short-term during pregnancy. Not enough is known about using L-arginine long-term in pregnancy or during breast-feeding. Stay on the safe side and avoid use.
Children: L-arginine is POSSIBLY SAFE when used by mouth in premature infants in appropriate doses. However, L-arginine is POSSIBLY UNSAFE when used in high doses. Doses that are too high can cause serious side effects including death in children.
Allergies or asthma: L-arginine can cause an allergic response or make swelling in the airways worse. If you are prone to allergies or asthma and decide to take L-arginine, use it with caution.
Cirrhosis: L-arginine should be used with caution in people with cirrhosis.
Guanidinoacetate methyltransferase deficiency: People with this inherited condition are unable to convert arginine and other similar chemicals into creatine. To prevent complications associated with this condition, these people should not take arginine.
Herpes: There is a concern that L-arginine might make herpes worse. There is some evidence that L-arginine is needed for the herpes virus to multiply.
Low blood pressure: L-arginine might lower blood pressure. This could be a problem if you already have low blood pressure.
Recent heart attack: There is a concern that L-arginine might increase the risk of death after a heart attack, especially in older people. If you have had a heart attack recently, don’t take L-arginine.
Kidney disease: L-arginine has caused high potassium levels when used by people with kidney disease. In some cases, this has resulted in a potentially life-threatening irregular heartbeat.
Surgery: L-arginine might affect blood pressure. There is a concern that it might interfere with blood pressure control during and after surgery. Stop taking L-arginine at least 2 weeks before a scheduled surgery.
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