Lesinurad: Uses, Side Effects

Lesinurad helps the kidneys remove uric acid from the body. Lesinurad is used together with other medicines that can cause the body to produce less uric acid.

Lesinurad is used as part of a combination of medicines to treat high levels of uric acid in your blood, also called hyperuricemia. High levels of uric acid can lead to a condition called gout.

Lesinurad should be used together with allopurinol (Zyloprim) or febuxostat (Uloric). Lesinurad should not be used alone.

Lesinurad may also be used for purposes not listed in this medication guide.


Important Information

You should not use lesinurad if you have severe kidney problems, or if you are on dialysis or have received a kidney transplant.

Lesinurad can cause kidney failure, especially if you take it without your other prescribed medications. Call your doctor right away if you urinate less than usual or not at all, or if you have swelling in your feet or ankles, or shortness of breath.

Before taking this medicine

You should not use lesinurad if you are allergic to it, or if:

  • you have severe kidney disease;
  • you are on dialysis;
  • you received a kidney transplant;
  • you have Lesch-Nyhan syndrome (a genetic condition that increases uric acid levels in the blood); or
  • you have tumor lysis syndrome (rapid breakdown of cancer cells).

To make sure lesinurad is safe for you, tell your doctor if you have ever had:

  • kidney disease;
  • liver disease;
  • heart disease; or
  • a stomach disorder called gastroesophageal reflux disease (GERD).

It is not known whether this medicine will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.

Lesinurad can make birth control pills less effective. Ask your doctor about using a non hormonal birth control (condom, diaphragm with spermicide) to prevent pregnancy.

Other forms of hormonal contraception (injections, implants, skin patches, vaginal rings, and certain intrauterine devices) may not be effective enough to prevent pregnancy during your treatment with lesinurad.

It is not known whether lesinurad passes into breast milk or if it could harm a nursing baby. Tell your doctor if you are breast-feeding a baby.

Lesinurad is not approved for use by anyone younger than 18 years old.


Side effects

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

  • gout flare-up symptoms–joint pain, stiffness, redness, or swelling (especially at night);
  • kidney problems–little or no urination, swelling in your feet or ankles, feeling tired or short of breath;
  • heart problems–chest pain or pressure, pain spreading to your jaw or shoulder; or
  • signs of a blood clot–sudden numbness or weakness, problems with vision or speech, swelling or redness in an arm or leg.

Common side effects may include:

  • abnormal kidney function tests;
  • heartburn;
  • headache; or
  • flu-like symptoms.

What other drugs will affect lesinurad?

Many drugs can interact with lesinurad. Not all possible interactions are listed here. Tell your doctor about all your current medicines and any you start or stop using, especially:

  • aspirin;
  • valproic acid;
  • an antibiotic or antifungal medicine;
  • cholesterol medication;
  • heart or blood pressure medication;
  • hormonal birth control (pills, patches, implants, or certain intrauterine devices); or
  • other gout medications.

Keyword: lesinurad.

* The Content is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition.