Lisinopril: Uses, Side Effects

Lisinopril is an ACE inhibitor. ACE stands for angiotensin converting enzyme.

Lisinopril is used to treat high blood pressure (hypertension) in adults and children who are at least 6 years old.

Lisinopril is also used to treat congestive heart failure in adults, or to improve survival after a heart attack.

Before taking this medicine

You should not use lisinopril if you are allergic to it, or if you:

  • have a history of angioedema;
  • recently took a heart medicine called sacubatril; or
  • are allergic to any other ACE inhibitor, such as benazepril, captopril, enalapril, fosinopril, moexipril, perindopril, quinapril, ramipril, or trandolapril.

Do not take lisinopril within 36 hours before or after taking medicine that contains sacubatril (such as Entresto).

If you have diabetes, do not use lisinopril together with any medication that contains aliskiren (such as Tekturna or Tekamlo).

You may also need to avoid taking lisinopril with aliskiren if you have kidney disease.

You should not use this medicine if you have hereditary angioedema.

To make sure lisinopril is safe for you, tell your doctor if you have ever had:

  • kidney disease (or if you are on dialysis);
  • liver disease; or
  • high levels of potassium in your blood.

Do not use lisinopril if you are pregnant. If you become pregnant, stop taking this medicine and tell your doctor right away. This medicine can cause injury or death to the unborn baby if you take the medicine during your second or third trimester. Use effective birth control while taking lisinopril.

It is not known whether lisinopril passes into breast milk or if it could harm a nursing baby. You should not breast-feed while using lisinopril.

Side effects

Get emergency medical help if you have signs of an allergic reaction to lisinopril: hives; severe stomach pain, difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

  • a light-headed feeling, like you might pass out;
  • fever, sore throat;
  • high potassium – nausea, weakness, tingly feeling, chest pain, irregular heartbeats, loss of movement;
  • kidney problems – little or no urination, swelling in your feet or ankles, feeling tired or short of breath; or
  • liver problems – nausea, upper stomach pain, itching, tired feeling, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes).

Common lisinopril side effects may include:

  • headache, dizziness;
  • cough; or
  • chest pain.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.

What other drugs will affect lisinopril?

Tell your doctor about all your current medicines and any you start or stop using, especially:

  • a diuretic or “water pill”;
  • lithium;
  • gold injections to treat arthritis;
  • insulin or oral diabetes medicine;
  • a potassium supplement;
  • medicine to prevent organ transplant rejection – everolimus, sirolimus, tacrolimus, temsirolimus; or
  • NSAIDs (nonsteroidal anti-inflammatory drugs) – aspirin, ibuprofen (Advil, Motrin), naproxen (Aleve), celecoxib, diclofenac, indomethacin, meloxicam, and others.

This list is not complete. Other drugs may interact with lisinopril, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide.


Keyword: lisinopril.

* The Content is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition.