Methylmalonic Acid-Reference Range

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Methylmalonic acid test is very important in detectingĀ early and/or mild vitamin B12 deficiency, or a rare inherited metabolic disorder called methylmalonic acidemia.

Methylmalonic acid (MMA) is a substance produced in small amounts and is necessary for human metabolism and energy production. Generally, the normal levels of methylmalonic acid are between 0.00 and 0.40 umol/L (micromoles per liter).

If you have symptoms like numbness, tingling in the hands or feet, swollen body tissues, walking problems, yellow skins or eyes, etc. You may need to take this test.

Tests results are as follows:

If MMA and homocysteine levels are elevated and the vitamin B12 level is mildly decreased, early or mild B12 deficiency may be diagnosed.

If only the homocysteine level is elevated and not MMA, folate deficiency may be diagnosed.

If both MMA and homocysteine levels are normal, there exists no B12 deficiency.

Moderately to severely elevated levels of MMA may be seen in infants with the rare inherited disease methylmalonic acidemia.

Keywords: Methylmalonic Acid; MMA

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