Natpara: Uses & Side Effects

Natpara (parathyroid hormone) is a manmade form of a hormone that occurs naturally in the body. Natpara is used together with calcium and vitamin D to treat hypocalcemia (low levels of calcium in the blood) in people who also have low levels of parathyroid hormone.

Natpara is usually given after calcium and vitamin D alone have been tried without success.

Natpara is available only under a special program. You must be registered in the program and understand the risks and benefits of this medicine.

How should I use Natpara?

Take Natpara exactly as prescribed by your doctor. Follow all directions on your prescription label and read all medication guides or instruction sheets.

Natpara is injected under the skin. A healthcare provider may teach you how to properly use the medication by yourself.

Read and carefully follow any Instructions for Use provided with your medicine. Ask your doctor or pharmacist if you don’t understand all instructions.

Use only the cartridges and injection pen provided with the medicine. Do not use a syringe to inject Natpara.

Do not shake the cartridge or you may ruin the medicine. Prepare an injection only when you are ready to give it. Do not use if the medicine has changed colors. Call your pharmacist for new medicine.

You will need frequent medical tests while using this medicine and for a short time after your last dose.

Do not change your dose or stop using Natpara without your doctor’s advice. You could have dangerously low calcium levels if you stop using this medicine suddenly.

Store in the refrigerator, do not freeze. Protect from heat and light.

Each Natpara cartridge contains enough medicine for 14 separate injections. Throw the cartridge away after 14 uses, even if there is still medicine left inside.

Do not throw away the injection pen. It can be used for up to 2 years if you change the cartridge every 14 days.


You should not use Natpara if you are allergic to parathyroid hormone.

In animal studies, parathyroid hormone caused bone cancer. However, it is not known whether these effects would occur in humans. Ask your doctor about your risk.

To make sure Natpara is safe for you, tell your doctor if you have ever had:

  • high levels of calcium in your blood;
  • high levels of alkaline phosphatase in your blood;
  • bone cancer;
  • Paget’s disease or other bone disorders;
  • radiation treatment.

It is not known whether this medicine will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.

You should not breast-feed while using this medicine.

Natpara is not approved for use by anyone younger than 18 years old, or by anyone whose bones are still growing.

Side Effects

Get emergency medical help if you have signs of an allergic reaction to Natpara: hives, itching; fast heartbeats, feeling light-headed, difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

  • new or unusual pain that is ongoing;
  • swelling or tender lumps under your skin;
  • a seizure;
  • high calcium levels – nausea, vomiting, constipation, increased thirst or urination, muscle weakness, bone pain, confusion, lack of energy, or tired feeling.

After you stop using this medicine, you may have low calcium levels. Tell your doctor if you have numbness or tingling around your mouth or in your fingers and toes, muscle twitching in your face, cramps in your hands and feet, mood changes, or problems with thinking or memory.

Common Natpara side effects may include:

  • tingling, burning, or prickly feeling in your skin;
  • headache;
  • nausea, vomiting, diarrhea;
  • joint pain.


Tell your doctor about all your other medicines, especially:

  • alendronate (Fosamax);
  • digoxin;
  • vitamin or mineral supplements that contain calcium or vitamin D.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Keyword: Natpara.

* The Content is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition.