Olsalazine: Uses & Side Effects

Olsalazine (Dipentum) affects substances in the body that cause inflammation, tissue damage, and diarrhea.

Olsalazine is used to treat ulcerative colitis.

Before taking this medicine

You should not use this medication if you are allergic to olsalazine or to salicylates such as aspirin, Novasal, Doan’s Extra Strength, Salflex, Tricosal, and others.

Before taking olsalazine, tell your doctor if you are allergic to any drugs, or if you have:

  • asthma or other allergies;
  • kidney disease; or
  • liver disease.

If you have any of these conditions, you may need a dose adjustment or special tests to safely take olsalazine.

FDA pregnancy category C. This medication may be harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment.

Olsalazine can pass into breast milk and may harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

Side effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Stop using olsalazine and call your doctor at once if you have any of these serious side effects:

  • worsening colitis (fever, stomach pain, cramping, or bloody diarrhea);
  • chest pain, shortness of breath, fast or pounding heartbeats; or
  • nausea, stomach pain, loss of appetite, itching, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes).

Less serious side effects may include:

  • mild stomach discomfort;
  • nausea, heartburn;
  • skin rash, itching;
  • headache;
  • muscle or joint pain; or
  • urinating more often than usual.


Keywords: Olsalazine; Dipentum.

* The Content is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition.