PGSN-Progesterone: Progesterone is a hormone made by a woman’s ovaries, whose main role is to help prepare a woman’s body for pregnancy. It works in conjunction with several other female hormones.

The normal reference value of Progesterone for female:

  • <4 days old: not established
  • 4 days-<12 months: < or =1.3 ng/mL (confidence interval 0.88-2.3 ng/mL)
  • 12 months-9 years: < or =0.35 ng/mL
  • 10-17 years: refer to adults concentrations
  • Adult (90% of health population):
    • Follicular phase: < or =0.89 ng/mL
    • Ovulation : < or =12 ng/mL
    • Luteal phase: 1.8-24 ng/mL
  • Pregnancy
    • 1st trimester: 11-44 ng/mL
    • 2nd trimester: 25-83 ng/mL
    • 3rd trimester: 58-214 ng/mL
  • Post-menopausal: < or =0.20 ng/mL


If progesterone levels do not rise and fall on a monthly basis, a woman may not be ovulating nor having regular menstrual periods. This may be a cause of infertility.

If levels do not rise normally during an early pregnancy, the pregnancy may be ectopic and/or may be failing. If serial measurements do not show increasing progesterone levels over time, there may be problems with the viability of the placenta and fetus.

Increased progesterone levels are seen occasionally with:

  • Some ovarian cysts
  • Non-viable pregnancies known as molar pregnancies
  • A rare form of ovarian cancer
  • Overproduction of progesterone by the adrenal glands
  • Adrenal cancer
  • Congenital adrenal hyperplasia (CAH)

Low levels of progesterone may be associated with:

  • Toxemia late in pregnancy
  • Decreased function of ovaries
  • Lack of menstruation (amenorrhea)
  • Ectopic pregnancy
  • Fetal death/miscarriage
* The Content is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition.