Porphyrins Blood Test-Reference Range

Porphyrins help form many important substances in the body. One of these is hemoglobin. This is the protein in red blood cells that carries oxygen in the blood. This test is used to diagnose porphyrias. It may also be used along with other tests to diagnose lead poisoning and certain nervous system and skin disorders.

Normal range

This test specifically measures total porphyrin levels. But, reference values (a range of values seen in a group of healthy people) for the individual components are also included:

  • Total porphyrin levels: 0 to 1.0 mcg/dL (0 to 15 nmol/L)
  • Coproporphyrin level: <2 mcg/dL (<30 nmol/L)
  • Protoporphyrin level: 16 to 60 mcg/dL (0.28 to 1.07 μmol/L)
  • Uroporphyrin level: <2 mcg/dL (<2.4 nmol/L)

Increased levels of protoporphyrin may indicate:

  • Anemia of chronic disease
  • Thalassemia
  • Lead poisoning
  • Iron deficiency anemia
  • Increased erythropoiesis
  • Sideroblastic anemia
  • Infection
  • Congenital erythropoietic protoporphyria
  • Variegate porphyria

Increased levels of coproporphyrins may indicate:

  • Congenital erythropoietic porphyria
  • Sideroblastic anemia
  • Variegate porphyria
  • Hepatic coproporphyria

Increased levels of uroporphyrin may indicate:

  • Congenital erythropoietic porphyria
  • Porphyria cutanea tarda

Keywords: porphyrins blood test

* The Content is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition.