Raloxifene: Uses, Side Effects

Raloxifene affects the cycle of bone formation and breakdown in the body, and reduces loss of bone tissue.

Raloxifene is used to treat or prevent osteoporosis in postmenopausal women. Raloxifene is also used to reduce the risk of invasive breast cancer in postmenopausal women who have osteoporosis or who are otherwise at risk of invasive breast cancer.

Raloxifene is not a cancer medication and will not treat breast cancer.

Raloxifene may also be used for purposes not listed in this medication guide.

Important Information

Taking raloxifene may increase your risk of a blood clot in your leg, your lung, or your eye. You should not take raloxifene if you have ever had a blood clot.

Raloxifene can also increase your risk of a stroke, which can be fatal. This risk is highest if you have coronary heart disease or certain risk factors (such as menopause, diabetes, smoking, being overweight, having high blood pressure or high cholesterol, having a family history of coronary artery disease, or if you have had a hysterectomy).

Do not take raloxifene if you are pregnant or may become pregnant.

Do not breast-feed while taking raloxifene.

Before taking this medicine

You should not use raloxifene if you are allergic to it, or if you have had a blood clot in your leg, your lung, or your eye.

Raloxifene can increase your risk of a stroke, which can be fatal. This risk is highest if you have coronary heart disease or certain risk factors (such as menopause, diabetes, smoking, being overweight, having high blood pressure or high cholesterol, having a family history of coronary artery disease, or if you have had a hysterectomy).

Raloxifene is not for use in men.

Tell your doctor if you have ever had:

  • heart disease;
  • coronary artery disease (clogged arteries);
  • a stroke or blood clot;
  • breast cancer;
  • liver or kidney disease;
  • abnormal vaginal bleeding; or
  • if you have not gone through menopause.

This medicine is for use only in women who can no longer get pregnant. Raloxifene can harm an unborn baby. Do not use if you are pregnant. Use effective birth control if you are not past menopause. Tell your doctor if you think you may be pregnant.

You should not breast-feed while using this medicine.

Side effects

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Stop using raloxifene and call your doctor at once if you have:

  • lumps or other changes in the breast;
  • signs of a stroke–sudden numbness or weakness (especially on one side of the body), sudden severe headache, slurred speech, problems with vision or balance;
  • signs of a blood clot in the lung–chest pain, sudden cough, wheezing, rapid breathing, coughing up blood; or
  • signs of a blood clot in your leg–pain, swelling, warmth, or redness in one or both legs.

Common side effects may include:

  • hot flashes;
  • leg cramps;
  • swelling in your hands, feet, or ankles;
  • joint pain;
  • flu symptoms; or
  • increased sweating.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.

What other drugs will affect raloxifene?

Other drugs may affect raloxifene, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.


Keyword: raloxifene.

* The Content is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition.