Research shows it's possible to reverse damage caused by aging cells

Aging starts in our cells, and those aging cells can hasten cellular senescence, leading to tissue dysfunction and related health impacts. Lately scientists have proved that there are types of small molecules that can reverse the impact of aged, senescent cells. Such small molecules are called senolytics. 

In the research scientists transplanted a relatively small number of senescent(aging) cells to surround healthy cells. Surprisingly, the transplant caused persistent physical dysfunction as well as the spread of cellular senescence(aging) in previously healthy cells.

In addition, researchers found that a high fat diet, which causes a type of metabolic stress, or simply being old, enhances the physical dysfunction that comes from senescent cells. That also proves in a way that a high fat diet speeds up the aging process.

Conversely, the researchers use senolytic drugs to treat or eliminate senescent cells, the treatment reversed physical dysfunction and actually extended lifespan when used in aged animal models.

“We saw greater activity, more endurance, and greater strength following use of senolytics,” said Dr. Robbins from the core research team.

“This area of research is promising, not just to address the physical decline that comes with aging, but also to enhance the health of cancer survivors treated with radiation or chemotherapy—two treatments that can induce cell senescence,” said Laura Niedernhofer, Director of iBAM.



* The Content is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition.