Serum N-Terminal Telopeptide (serum NTX): Interpretation & Reference Values

In bone physiology, N-terminal telopeptide (NTX) is a telopeptide that can be used as a biomarker to measure the rate of bone turnover.

NTX can be measured in the urine (uNTX) or serum (serum NTX).


It can be used to monitor effectiveness of antiresorptive therapy in patients treated for osteoporosis or other metabolic bone disorders


Elevation of NTX level means bone resorption has increased.

Reference Values

All units are reported in nmol Bone Collagen Equivalents (BCE)
For adults (> or =18 years of age):

  • Males: 5.4-24.2 nmol BCE
  • Females: Premenopausal: 6.2-19.0 nmol BCE

The target value for postmenopausal adult females undergoing treatment for osteoporosis is the same as the premenopausal reference interval.


Serum N-terminal telopeptide cannot be used for the screening or diagnosis of osteoporosis.

Consult your doctors for more details.

Keywords: serum N-terminal telopeptide; serum NTX; NTX.

* The Content is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition.