T-Cell Receptor Gene Rearrangement Testing

T-cell receptor gene rearrangement testing detects characteristic changes in specific genes in T-cells to help diagnose a T-cell lymphoma.

Positive results of T-cell population may indicate:

  • Adult T-cell leukemia/lymphoma (ATLL)
  • Anaplastic large-cell lymphoma
  • Angioimmunoblastic T-cell lymphoma
  • Enteropathy-associated T-cell lymphoma
  • Hepatosplenic T-cell lymphoma
  • Extranodal NK/T-cell lymphoma, nasal type
  • Peripheral T-cell lymphoma
  • Precursor T-cell neoplasm
  • T-cell large granular lymphocytic leukemia
  • T-cell prolymphocytic leukemia

Negative results of T-cell population may indicate:

  • No leukemia
  • Leukemia

It should be notice that a negative result on the test does not necessarily rule out a lymphoma. A person with a negative result for a clonal T-cell receptor gene rearrangement may still have lymphoma. A test may also be negative if the test method is not sensitive enough to detect the rearrangement or if the clonal lymphocytes from the person tested have mutations that are not detected by the test, or if the lymphoma is of the B-cell type.

Keywords: T-cell receptor gene rearrangement testing

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