Vancomycin Test - Normal Range

  • Trough reference range: 10-20 µg/mL.
  • Peak reference range: 30-50 µg/mL.

Vancomycin is one of the most widely used antibiotics for the treatment of serious gram-positive infections involving methicillin-resistant S. aureus (MRSA) and has been in clinical use for nearly 50 years.

Guidelines from 2009 by pharmacists and infectious disease specialists recommend that only trough levels be performed, with a minimum of 10 mcg/mL considered necessary to control an infection.

However, many institutions have specific ranges depending on the site of infection and severity of infection.

If trough levels of vancomycin are above the minimum level, then the person should be receiving enough of the drug to be effective.

If the person’s infection is not responding to the treatment, then the health practitioner may either continue the drug for a longer period of time or consider other treatment options.

If peak concentrations are below maximum levels, then the treated person is at less risk of developing nephrotoxicity and/or ototoxicity but may still experience either complication. Peak concentrations may vary, depending on the consistency of collection timing and on changing drug clearance rates.

If the trough and/or peak concentrations are above the maximum levels, then the person is at an increased risk of toxicity and the health practitioner may either alter the dose or the dosing schedule.

Keyword: vancomycin

* The Content is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition.