What Are the Basics of Liposarcoma?

What is liposarcoma?

Liposarcoma is a malignant tumor that arises in fat cells in deep soft tissue. It is one type of soft tissue sarcomas, mainly affecting middle-age people at sites such as the thigh, gluteal region, retroperitoneum, and leg and shoulder area.

Liposarcoma can be categorized into following three families:

  • well-differentiated and/or dedifferentiated (50%)
  • myxoid and/or round cell (40%)
  • pleomorphic (10%)

Each of the family has its own specific biology and risk of recurrence or spread, as such, each requires its own unique treatment.

What are the signs and symptoms of liposarcoma?

Signs and symptoms of liposarcomas vary depending on the location of the tumor and the extent to which it has spread in the body.

Symptoms and signs that may occur later in the disease can include

  • painful swelling and/or a growing lump under the skin;
  • numbness;
  • enlargement of varicose veins;
  • fatigue and/or weakness, especially of the affected limb;
  • abdominal pain, and/or blood in the stool (these symptoms are more likely to develop in patients
  • with liposarcoma the forms in the abdomen);
  • chest pain;
  • urinary difficulty and/or pain;
  • difficulty swallowing;
  • nausea;
  • vomiting;
  • decreased range of motion in the limbs.

What are the causes or risk factors of liposarcoma?

It is not clear what causes liposarcoma.

Risk factors for liposarcoma may include:

  • Radiation
  • Certain family cancer syndrome (e.g. neurofibromatosis, Gardner syndrome)
  • A damaged lymph system
  • Exposure to certain chemicals (e.g. vinyl chloride, dioxin)

What are the treatment options for liposarcoma?

Treatment options vary depending on the stages of liposarcoma. The stages range from I to IV, with IV representing the most extensive cancer with metastatic spread.

Treatment options for liposarcoma include:

  • Surgery
  • Radiation therapy
  • Chemotherapy
  • Clinical trials

What is the prognosis of liposarcoma?

According to Wikipedia, the prognosis varies depending on the site of origin, the type of cancer cell, the tumor size, the depth, and proximity to lymph nodes.

Well-differentiated liposarcomas treated with surgery, intra-operative distilled water lavage and radiation have a low recurrence rate (about 10%) and rarely metastasize.

Five-year survival rates vary from 100% to 56% based on histological subtype.

Keywords: liposarcoma; liposarcoma cancer; myxoid liposarcoma; early symptoms liposarcoma; liposarcoma symptoms; causes liposarcoma; treatment liposarcoma; liposarcoma prognosis; liposarcoma staging

* The Content is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition.