What Are the Duke Criteria of Infective Endocarditis?

What are the Duke criteria of infective endocarditis?

The Duke criteria of infective endocarditis include major criteria and minor criteria.

Major criteria

  1. Positive blood culture results for infective endocarditis
  • Typical microorganism from two separated blood cultures
  • Viridans streptococci, S. bovis, HACEK group, or community-acquired S. aureus or enterococci without a primary focus
  1. Persistently positive blood culture results for a microorganism suggestive of infective endocarditis
  • Blood culture drawn more than 12 hours apart
  1. All three or a majority of four or more separate blood cultures, with the first and last drawn at least 1 hour apart
  • Evidence of endocardial involvement

Echocardiogram showing an oscillating intracardiac mass in the absence of alternative anatomic explanation, abscess, or new partial dehiscence of a prosthetic valve

  1. New valvular regurgitation (increase or change in preexisting murmur not sufficient)

Minor criteria

  1. Predisposing heart disease or intravenous drug use
  2. Fever >38.0℃(100.4℉)
  3. Vascular phenomena
  4. Immunologic phenomena
  5. Microbiologic evidence not meeting a major criterion or serologic evidence of active infection
  6. Consistent echocardiogram not meeting a major criterion

IE is diagnosed if two major criteria, or one major and three minor criteria, or five minor criteria are met, or if surgical or autopsy specimens meet pathologic criteria.


Keywords: duke criteria endocarditis; duke criteria infective endocarditis; endocarditis criteria; infective endocarditis criteria.



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